HA5® Hydra Collagen Replenish + Restore Hydrator
$121.50 $192.
This price is available only in the spa. Appointment Required
An Evolution in Hydration - Introducing the next-gen
HA5®, now with 2X more hyaluronic acid. Enhanced with Hydra Collagen for instant hydration and smoothness, plus Advanced VITISENSCE® Technology to replenish natural humectants, including HA and help restore skin's hydration reservoir.
Provides immediate hydration lasting up to 48 hours. Enjoy visibly plump, dewy, and healthier-looking skin with fewer lines.
HA®® Hydra Collagen Replenish + Restore Hydrator attracts and retains water for instant hydration and visibly plump, smooth skin
-In a clinical study, patients reported they looked ~ 3years younger by week 12
-Clinically proven to improve hydration and support skin health by addressing the skin barrier and water-holding capacity
Clinically proven to:
HA⁵® Hydra Collagen Replenish + Restore Hydrator attracts and retains water for instant hydration and visibly plump, smooth skin
In a clinical study, patients reported they looked ~ 3 years younger by week 12
Clinically proven to improve hydration and support skin health by addressing the skin barrier and water-holding capacity
Key Ingredients:
Advanced VITISENSCE® Technology
Features a blend of nutrients found in nature, targeting existing collagens within the skin to boost hydration naturally.
Avocado Oil Esters - Supports skin's natural hydration and skin's water-holding abilities
Vitamin F - Supports skin barrier and prevents water loss
Passion Fruit Seed Oil - Enhances skin health and supports skin's water and nutrition flow
Vitis Flower Stem Extract and Lotus Sprout Extract - Protect against oxidative stress
Proprietary HA⁵® Hydra Collagen Complex
Hydration Collagen - vegan collagen that attracts and retains water for instant hydration and smoothness
5 Forms of HA:
Vectorized Time Release HA - A SkinMedica® proprietary ingredient for sustained release of HA
Cross-linked HA - Provides long-lasting hydration
Liposomally Encapsulated HA - For immediate hydration
Noncross-linked HA - For smoothness and hydration
Nano-hyaluronic acid - Soothes skin
For all skin types • TSA Friendly • Silicone-free • Non-comedogenic • Sulfate-free • Lightweight • Fragrance-free • Paraben-free • Pilling-free
There's skincare. Then there's scientific skincare.
And with over 80 beauty award wins! SkinMedica is recognized as a leader in aesthetics.
Proof is in the Science
Explore peer-reviewed publications that show the impact of growth factors
Fitzpatrick RE, Rostan, EF. Reversal of photodamage with topical growth factors: a pilot study. J Cosmet Laser Ther. 2003:5:25-34.
Fitzpatrick RE. Treatment of photodamaged and aging skin with a unique cream: 3 Case reports. Cosmet Dermatol. 2004; 17(9):591-596.
Mehta RC, Fitzpatrick RE. Endogenous growth factors as cosmeceuticals. Dermatol Ther. 2007;Sep-Oct;20(5):350-9. .
Mehta RC, Smith SR, Grove GL, et al. Reduction in facial photodamage by a topical growth factor product. J Drugs Dermatol. 2008;7864-871. .
Trookman NS, Rizer RL, Ford R, et al. Immediate and long-term clinical benefits of a topical treatment for facial lines and wrinkles. J Clin Aesthet Dermatol. 2009; 2(3):38-43.
Sundaram H, Mehta RC, Norine JA, Kircik L, et al. Topically applied physiologically balanced growth factors: a new paradigm of skin rejuvenation. J Drugs Dermatol. 2009 May;8(5 Suppl Skin Rejuvenation):4-13.
Trookman NS, Rizer RL, Ford R, et al. Clinical assessment of a combination lip treatment to restore moisturization and fullness. J Clin Aesthet Dermatol. 2009; 2(12):44-48.
Atkin DH, Trookman NS, Rizer RL, et al. Combination of physiologically balanced growth factors with antioxidants for reversal of facial photodamage. J Cosmet Laser Ther. 2010; 12:14-20.
Kadoya K, Makino ET, Jiang, LI, et al. Upregulation of Extracellular Matrix Genes Corroborates Clinical Efficacy of Human Fibroblast-Derived Growth Factors in Skin Rejuvenation. J Drugs Dermatol. 2017; 16(12):1190-6.
Naughton GK, Jiang LI, Makino ET, et al. Targeting Multiple Hallmarks of Skin Aging: Preclinical and Clinical Efficacy of a Novel Growth Factor-Based Skin Care Serum. Dermatol Ther. 2023 Jan;13(1):169-186.
Gold MH, Wilson A, Makino E, et al. Improvements in Skin Quality Parameters in Postmenopausal Participants After Use of Topical Growth Factor Serum. J Cosmet Dermatol. 2023 Jan;22(1):236-244.
Goldman MP, Boen M, Deaver J, et al. Effects of a Topical Growth Factor Regimen Following Pre-elected Cosmetic Facial Injection Procedures. J Drugs Dermatol. 2023 Jan 1;22(1):9-15.
Kellar RS, Hubka M, Rheins LA, et al. Hypoxic conditioned culture medium from fibroblasts grown under embryonic-like conditions supports healing following post-laser resurfacing. J Cosmetic Derm. 2009; 8(3):190-196.
Pinney E, Zimber M, Schenone A, et al. Human Embryonic-like ECM (hECM) Stimulates Proliferation and Differentiation in Stem Cells While Killing Cancer Cells. Int J Stem Cells 2011; 4(1):70-75.
Zimber MP, Mansbridge JN, Taylor M, et al. Human cell-conditioned media produced under embryonic-like conditions result in improved healing time after laser resurfacing. Aesthetic Plast Surg. 2012; 36(2):431-437.
Bruce S, Karnik J, Dryer L, et al. Anti-aging proof of concept study: results and summary. J Drugs Dermatol. 2014; 13(9):1074-1081.
Sundaram H, Gold M, Waldorf H, et al. Pilot, Multicenter, Open-Label Evaluation of Safety, Tolerability and Efficacy of a Novel, Topical Multipotent Growth Factor Formulation for the Periorbital Region. J Drugs Dermatol. 2015; 14(12):1410-1417.
Draelos ZD, Karnik J, Naughton G. The Anti-Aging Effects of Low Oxygen Tension Generated Multipotent Growth Factor Containing Serum. J Drugs Dermatol. 2017; 16(1):30-34.
And many more at skinmedica.com