SkinMedica TNS Advanced+ Serum bottle with Allure beauty award badge

TNS® Advanced+ Serum

$172.50 $295.

This price is available only in the spa. Appointment Required

This next-generation, skin rejuvenating formula improves the appearance of coarse wrinkles, fine lines, skin tone, and texture. It’s the only growth factor product proven to address sagging skin.

Visible results in just 2 weeks. Results continue to improve through 24 weeks of use.

  • Subjects felt increasingly more satisfied with continued use measured over 24 weeks.

  • A third-party, validated psychometric scale revealed that patients felt they looked up to 6 years younger after 12 weeks.

  • Significant improvements in the appearance of sagging skin after 8 weeks.

Woman holding a bottle of SkinMedica TNS Advanced+ Serum close to her face.

Clinically proven to:

  • Smooths visible coarse wrinkles and fine lines

  • Clinically proven to address sagging skin

  • Results starting in just 2 weeks

  • Progressive results measured over 24 weeks.

Key Ingredients:

  • Chamber 1:

    • TNS®-MR

      • This advanced formula acts on multiple levels to help get you to age-defying results.

    • Next-generation growth factor blend

      • supports healthy skin functions

    • Innovative peptide complex

      • nourishes your skin

    Chamber 2:

    • RENESSENSCE (RSC) ADVANCED

      • Specifically designed to support the results of the growth factor blend, this highly active blend of botanicals, marine extracts, and peptides includes

    • Marine extract

      • Supports skin's renewal processes

    • Green microalgae

      • Supports collagen and elastin levels

For all skin types • TSA Friendly • Silicone-free • Non-comedogenic • Sulfate-free • Lightweight • Fragrance-free • Paraben-free • Pilling-free

There's skincare. Then there's scientific skincare.

And with over 80 beauty award wins! SkinMedica is recognized as a leader in aesthetics.

Proof is in the Science

Explore peer-reviewed publications that show the impact of growth factors

  • Fitzpatrick RE, Rostan, EF. Reversal of photodamage with topical growth factors: a pilot study. J Cosmet Laser Ther. 2003:5:25-34.

  • Fitzpatrick RE. Treatment of photodamaged and aging skin with a unique cream: 3 Case reports. Cosmet Dermatol. 2004; 17(9):591-596.

  • Mehta RC, Fitzpatrick RE. Endogenous growth factors as cosmeceuticals. Dermatol Ther. 2007;Sep-Oct;20(5):350-9. .

  • Mehta RC, Smith SR, Grove GL, et al. Reduction in facial photodamage by a topical growth factor product. J Drugs Dermatol. 2008;7864-871. .

  • Trookman NS, Rizer RL, Ford R, et al. Immediate and long-term clinical benefits of a topical treatment for facial lines and wrinkles. J Clin Aesthet Dermatol. 2009; 2(3):38-43.

  • Sundaram H, Mehta RC, Norine JA, Kircik L, et al. Topically applied physiologically balanced growth factors: a new paradigm of skin rejuvenation. J Drugs Dermatol. 2009 May;8(5 Suppl Skin Rejuvenation):4-13.

  • Trookman NS, Rizer RL, Ford R, et al. Clinical assessment of a combination lip treatment to restore moisturization and fullness. J Clin Aesthet Dermatol. 2009; 2(12):44-48.

  • Atkin DH, Trookman NS, Rizer RL, et al. Combination of physiologically balanced growth factors with antioxidants for reversal of facial photodamage. J Cosmet Laser Ther. 2010; 12:14-20.

  • Kadoya K, Makino ET, Jiang, LI, et al. Upregulation of Extracellular Matrix Genes Corroborates Clinical Efficacy of Human Fibroblast-Derived Growth Factors in Skin Rejuvenation. J Drugs Dermatol. 2017; 16(12):1190-6.

  • Naughton GK, Jiang LI, Makino ET, et al. Targeting Multiple Hallmarks of Skin Aging: Preclinical and Clinical Efficacy of a Novel Growth Factor-Based Skin Care Serum. Dermatol Ther. 2023 Jan;13(1):169-186.

  • Gold MH, Wilson A, Makino E, et al. Improvements in Skin Quality Parameters in Postmenopausal Participants After Use of Topical Growth Factor Serum. J Cosmet Dermatol. 2023 Jan;22(1):236-244.

  • Goldman MP, Boen M, Deaver J, et al. Effects of a Topical Growth Factor Regimen Following Pre-elected Cosmetic Facial Injection Procedures. J Drugs Dermatol. 2023 Jan 1;22(1):9-15.

  • Kellar RS, Hubka M, Rheins LA, et al. Hypoxic conditioned culture medium from fibroblasts grown under embryonic-like conditions supports healing following post-laser resurfacing. J Cosmetic Derm. 2009; 8(3):190-196.

  • Pinney E, Zimber M, Schenone A, et al. Human Embryonic-like ECM (hECM) Stimulates Proliferation and Differentiation in Stem Cells While Killing Cancer Cells. Int J Stem Cells 2011; 4(1):70-75.

  • Zimber MP, Mansbridge JN, Taylor M, et al. Human cell-conditioned media produced under embryonic-like conditions result in improved healing time after laser resurfacing. Aesthetic Plast Surg. 2012; 36(2):431-437.

  • Bruce S, Karnik J, Dryer L, et al. Anti-aging proof of concept study: results and summary. J Drugs Dermatol. 2014; 13(9):1074-1081.

  • Sundaram H, Gold M, Waldorf H, et al. Pilot, Multicenter, Open-Label Evaluation of Safety, Tolerability and Efficacy of a Novel, Topical Multipotent Growth Factor Formulation for the Periorbital Region. J Drugs Dermatol. 2015; 14(12):1410-1417.

  • Draelos ZD, Karnik J, Naughton G. The Anti-Aging Effects of Low Oxygen Tension Generated Multipotent Growth Factor Containing Serum. J Drugs Dermatol. 2017; 16(1):30-34.

  • And many more at skinmedica.com